Publications from 2006

Rønø, B., Rømer J., Liu S., Bugge T.H., Leppla, S.H. & Kristjansen, P.E.G.:
Antitumor efficacy of a urokinase activation-dependent anthrax toxin.
Mol. Cancer Ther. 2006, 5:89-96.

Henic, E., Sixt, M., Hansson, S., Høyer-Hansen, G. & Casslén, B.:
EGF-stimulated migration in ovarian cancer cells is associated with decreased internalization, increased surface expression, and increased shedding of the urokinase plasminogen activator receptor.
Gynec, Oncol. 2006, 101:28-39.

Porter, S., Span, P.N., Sweep, F.C.G.J., Tjan-Heijnen, V.C.G., Pennington, C.J., Pedersen, T.X., Johnsen, M., Lund, L.R., Rømer, J. & Edwards, D.R.:
ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma.
Int. J. Cancer. 2006, 118:1241-1247.

Nygaard, U., Larsen, J., Kristensen, T.D., Wessenberg, F., Jonsson, O.G., Carlsen, N.T. Forestier, E., Kirchhoff, M., Larsen, J.K., Schmiegelow, K. & Christensen, I.J.:
Flow cytometric DNA index, G-band karyotyping, and comparative genomic hybridization in detection of high hyperdiploidy in childhood acute lymphoblastic leukemia.
J. Pediat. Hematol. Oncol., 2006, 28:134-140.

Lindberg, P., Larsson, Å. & Nielsen, B.S.:
Expression of plasminogen activator inhibitor-1 (PAI-1), urokinase receptor (uPAR) and laminin (-2 chain (Lam5) is an early coordinated event in incipient oral squa mous cell carcinoma.
Int. J. Cancer. 2006, 118:2948-2956.

Pappot H., Pedersen, A.N., Brünner, N. & Christensen, I.J.:
The complex between urokinase (uPA) and its type-1 inhibitor (PAI-1 in pulmonary adenocarcinoma: Relation to prognosis.
Lung Cancer. 2006, 51:193-200.

List, K., Szabo, R., Molinolo, A., Nielsen, B.S. & Bugge, .T.H.:
Delineation of matriptase protein expression by enzymatic gene trapping suggests diverging roles in barrier function, hair formation, and squamous cell carcinogenesis.
Am. J. Pathol., 2006, 168:1513-1525.

Hobson, J.P., Liu, S., Rønø, B., Leppla, S.H. & Bugge, T.H.:
Imaging specific cell-surface proteolytic activity in single living cells.
Nat. Methods., 2006, 3:259-261.

Piironen, T., Haese, A., Huland, H., Steuber, T., Christensen, I.J., Brünner, N., Danø, K., Høyer-Hansen, G. & Lilja, H.:
Enhanced discrimination of benign from malignant prostatic disease by novel selective measurements of cleaved forms of urokinase receptor in serum.
Clin. Chem., 2006, 52:838-844.

Chaurasia, P., Aguirre-Ghiso, J.A., Liang, O.D., Gårdsvoll, H., Ploug, M. & Ossowski, L.:
A region in uPAR domain III controlling a functional association with α5β1 - integrin and tumor growth.
J. Biol. Chem., 2006, 281:14852-14863.

Illemann, M., Bird, N., Majeed, A., Sehested, M., Laerum, O.D., Lund, L.R., Danø, K. & Nielsen, B.S.:
MMP-9 is differently expressed in primary human colorectal adenocarcinomas and their metastases.
Mol. Cancer Res., 2006, 4:293-302.

Liu, K., Wahlberg, P., Leonardsson, G., Hägglund, A.-C., Ny, A., Boden, I., Wibom, C., Lund, L.R. & Ny, T.:
Successful ovulation in plasminogen-deficient mice treated with the broad-spectrum matrix metalloproteinase inhibitor galardin.
Dev. Biol., 2006, 295:615-622.

Lund, L.R., Green, K.A., Stoop, A.A., Almholt, K., Lilla, J., Nielsen, B.S., Christensen, I.J., Craik, C.S., Werb, Z., Danø, K. & Rømer, J.:
Plasminogen actvation independent of uPA and tPA maintains wound healing in gene-deficient mice.
EMBO J., 2006, 25:2686-2697.

Vasiljeva. P., Papazoglou, A., Krüger, A., Brodoefel, H., Korovin, M., Deussing, J. Augustin, N., Nielsen, B.S., Almholt, K., Bogyo, M., Peters, C. & Reinheckel, T.:
Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.
Cancer Res., 2006, 66:5242-5250.

Rosenkilde, M.M., Benned-Jensen, T., Andersen, H., Holst, P., Kledal, T.N., Lüttichau, H.R., Larsen, J.K., Geisler, C., Christensen, J.P. & Schwartz, T.W.:
Molecular pharmacological phenotyping of EB12.An orphan seven-transmembrane receptor with constitutive activity.
J. Biol. Chem., 2006, 281:13199-13208.

Ostrowski, S.R., Katzenstein, T.L., Pedersen, M., Høyer-Hansen, G., Gerstoft, J., Pedersen, B.K. & Ullum, H.:
Plasma levels of intact and cleaved urokinase receptor decrease in HIV-1nfected patients initiating highly active antiretroviral therapy.-i
Scand. J. Immunol., 2006, 63:478-486.

Green, K.A., Nielsen, B.S., Castellino, F.J., Rømer, J. & Lund, L.R.:
Lack of plasminogen leads to milk stasis premature mammary gland involution during lactation.
Developmental Biol., 2006, 299: 164-175.

Stegmann, A., Hansen, M., Wang, Y., Larsen , J.B., Lund, L.R., Ritié, L, Nicholson, J.K., Quistorff, B., Simon-Assmann, P., Troelsen, J.T. & Olsen, J.:
Metabolome, transcriptome and bioinformatic cis-element analyses point to HNF-4 as a central regulator of gene expression during enterocyte differentiation.
Physiol. Genomics. 2006, 27: 141-155.

Ostrowski, S.R., Ravn, P., Høyer-Hansen, G., Ullum, H. & Andersen, A.B.:
Elevated levels of soluble urokinase receptor in serum from mycobacteria infected patients: Still looking for a marker of treatment efficacy.
Scand. J. Infect. Dis., 2006, 38:1028-1032.

Gårdsvoll, H., Gilquin, B., Le Du, M.H., Ménèz, A., Jørgensen, T.J.D- & Ploug, M.:
Characterization of the functional epitope on the urokinase receptor. Complete alanine scanning mutagenesis supplemented by chemical cross-linking.
J. Biol. Chem., 2006, 281:19260-19272.

Andersen, A.B., Law, I., Ostrowski, S.R., Lebech, A.M., Høyer-Hansen, G., Højgaard, L., Gerstoft, J., Ullum, H., Kjær, A.:
Self-report fatigue common among optimally treated HIV patients: no correlation with cerebral FDG-PET scanning abnormalities.
Neuroimmunomodulation. 2006, 13:69-75

Holten-Andersen, M.N., Nielsen, H.J., Sørensen S., Jensen, V., Brünner, N. & Christensen, I.J.:
Tissue inhibitor of metalloproteinases-1 in the postoperative monitoring of colorectal cancer.
Eur J Cancer, 2006, 42:1889-1896.

Davidsen ML, Würtz SØ, Rømer MU, Sørensen NM, Johansen SK, Christensen IJ, Larsen JK, Offenberg H, Brünner N, Lademann U:
TIMP-1 gene deficiency increases tumor cell sensitivity to chemotherapynduced apoptosis. -i
Brit J Cancer, 2006, 95: 1114-1120.