Ploug Group

Key publications

Gårdsvoll, H., Jacobsen, B., Kriegbaum, M.C., Behrendt, N., Engelholm, L.H., Østergaard, S., and Ploug, M.:
“Conformational regulation of urokinase receptor (uPAR) function. Impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction”.
J. Biol. Chem, 2011; in revision.

Kriegbaum, M., Persson, M., Haldager, L., Alpízar-Alpízar, W., Jacobsen, B., Gårdsvoll, H., Kjær, A., and Ploug, M.:
"Rational targeting of the urokinase receptor (uPAR): Development of antagonists and non - invasive imaging probes".
Current Drug Targets, 2011; in press

Lin, L., Gårdsvoll, H., Huai, Q., Huang, M., and Ploug, M.:
"Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: Implications for preclinical cancer therapy".
J Biol Chem. 2010; 285: 10982-92.

Li,Z-B., Niu, G., Wang, H., He, L., Yang, L., Ploug, M., and Chen, X.: "Imaging of urokinase-type plasminogen activator receptor expression using a 64Cu-labeled linear peptide antagonist by microPET"
Clin. Cancer Res. 2008, 14: 4758-4766.

Hansen, L.V., Lærum, O.D., Illemann, M., Nielsen, B.S., and Ploug, M.:
"Altered expression of the urokinase receptor homologue, C4.4A, in invasive areas of human esophageal squamous cell carcinoma"
Int. J. Cancer. 2008, 122: 734-741.

Gårdsvoll, H. and Ploug, M.:
"Mapping of the vitronectin binding site on the urokinase receptor. Involvement of a coherent receptor interface comprising residues from both domain I and the flanking interdomain linker region"
J. Biol. Chem. 2007, 282: 13561-135726.

Gårdsvoll, H., Gilquin, B., LeDu, M.H., Ménez, A., Jørgensen, T.D.J. and Ploug, M.:
"Charaterization of the functional epitope on the urokinase receptor. Complete alanine scanning mutagenesis supplemented by chemical crosslinking"
J. Biol. Chem. 2006, 281: 19260-192725.

Llinas, P., Le Du, M., Gårdsvoll, H., Danø, K., Ploug, M., Gilquin, B., Stura, E.A., and Ménez, A.:
"Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide"
EMBO J. 2005, 24: 1655-16633.

Ploug, M., Østergaard, S., Gårdsvoll, H., Kovalski, K., Holst-Hansen, C., Holm, A., Ossowski, L., and Danø, K.:
"Peptide derived antagonists of the urokinase receptor. Affinity maturation by combinatorial chemistry, identification of functional epitopes, and inhibitory effects on cancer cell intravasation"
Biochemistry. 2001, 40: 12157-121682.