Høyer-Hansen Group

Key Publications

Almasi, C.E., Brasso K., Iversen, P., Pappot, H., Høyer-Hansen, G., Danø, K. and Christensen, I.J.:
Prognostic and predictive value of intact and cleaved forms of the urokinase plasminogen activator receptor in metastatic prostate cancer.
Prostate, 2010; Epub ahead of print.

Thurison, T., Lomholt, A.F., Rasch, M.G., Lund, I.K., Nielsen, H.J., Christensen, I.J., and Høyer-Hansen, G.:
A new assay for the measurement of the liberated domain I of the urokinase receptor in plasma improves the prediction of survival in colorectal cancer.
Clin. Chem., 2010; 56:1636-40.

Jögi, A., Rønø, B., Lund, I.K., Nielsen B.S., Ploug, M., Høyer-Hansen, G,, Rømer, J. and Lund, L.R.:
Neutralisation of uPA with a monoclonal antibody reduces plasmin formation and delays skin wound healing in tPA-deficient mice.
PLoS One., 2010; 5:e12746

Henic, E., Borgfeldt, C., Christensen, I.J., Casslén, B. and Høyer-Hansen, G.:
Cleaved forms of the urokinase plasminogen activator receptor in plasma enhance discrimination of benign from malignant disease and predict survival in patients with ovarian cancer.
Clin Cancer Res., 2008; 14:5785-93.

Lund, I.K., Jögi, A., Rønø, B., Rasch, M.G., Lund, L.R., Almholt, K., Gårdsvoll, H., Behrendt, N., Rømer, J.R. and Høyer-Hansen, G.:
Antibody-mediated targeting of the urokinase-type plasminogen activator proteolytic function neutralizes fibrinolysis in vivo.
J Biol Chem., 2008; 283:32506-15.

Pass, J., Jögi, A., Lund,I.K., Rønø, B., Rasch,M.G., Gårdsvoll,H., Lund, L.R., Ploug, M., Rømer, J., Danø, K. and Høyer-Hansen, G.:
Murine monoclonal antibodies against murine uPA receptor produced in gene-deficient mice: Inhibitory effects on receptor-mediated uPA activity in vitro and in vivo.
Thromb.Haem. 2007; 97:1013-22.

Piironen, T., Haese, A., Huland, H., Steuber, T., Christensen, I.J., Brünner, N., Danø, K., Høyer-Hansen, G. and Lilja, H.:
Enhanced discrimination of benign from malignant prostatic disease by novel selective measurements of cleaved forms of urokinase receptor in serum.
Clin.Chem. 2006. 52: 838-844.

Piironen, T., Laursen, B., Pass, J., List, K., Gårdsvoll, H., Ploug ,M., Danø, K. and Høyer-Hansen, G.:
Specific immunoassays for the detection of intact and cleaved forms of the urokinase receptor.
Clin. Chem., 2004;50:2059-68.

Høyer-Hansen, G., Pessara, U., Holm,A., Pass, J., Weidle, U., Danø, K. and Behrendt, N.:
Urokinase-catalysed cleavage of the urokinase receptor requires an intact glycolipid anchor.
Biochem.J. 2001, 358:673-679.