Engelholm Group

All publications - 2001 to present

Szabova L, Yamada SS, Wimer H, Chrysovergis K, Ingvarsen S, Behrendt N, Engelholm LH, Holmbeck K.:
MT1-MMP and type II collagen specify skeletal stem cells and their bone and cartilage progeny.
J Bone Miner Res. 2009;24:1905-16.

Rowe, R.G., Li, X.Y., Hu, Y., Saunders, T.L., Virtanen, I., Garcia de Herreros, A., Becker, K.F., Ingvarsen, S., Engelholm, L.H., Bommer, G.T., Fearon, E.R. and Weiss, S.J.:
Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs.
J Cell Biol. 2009;184:399-408.

Engelholm, L.H., Ingvarsen, S., Jürgensen, H.J., Hillig, T., Madsen, D.H., Nielsen, B.S. and Behrendt, N.:
The collagen receptor uPARAP/Endo180.
Frontiers in Bioscience, 2009, 14: 2103-14

Juncker-Jensen, A., Rømer, J., Pennington, C.J., Lund, L.R., and Almholt, K.:
Spontaneous metastasis in matrix metalloproteinase 3-deficient mice.
Mol. Carcinogenesis. 2009, 48: 618-625.

Hillig, T., Engelholm, L.H. and Behrendt, N:
The Endocytic Collagen Receptor, uPARAP/Endo180, in Cancer Invasion and Tissue Remodeling.
In: The Cancer Degradome: Proteases and Cancer Biology. Edwards, D., Høyer-Hansen, G., Blasi, F. and Sloane, B.F. (eds.), Springer Science, 2008, Chapter 13, pp 245-258.

Ingvarsen, S., Madsen, D.H., Hillig, T., Lund, L.R., Holmbeck, K., Behrendt, N., Engelholm, L.H.:
Dimerization of endogenous MT1-MMP (MMP-14) is a regulatrory step in the activation of the the 72 kDa gelatinase (MMP-2) on fibroblastic and fibrosarcoma cells.
Biol. Chem., 2008, 389: 943-953.

Almholt, K., Juncker-Jensen, A., Lærum, O.D., Danø, K., Johnsen, M., Lund, L.R., and Rømer, J.:
Metastasis is strongly reduced by the matrix metalloprotease inhibitor galardin in the MMTV-PymT transgenic breast cancer model.
Mol.Cancer Ther. 2008, 7: 2758-2767.

Hillig, T., Engelholm, L.H., Ingvarsen, S., Madsen, D.H., Gårdsvoll, H., Larsen, J.K., Ploug, M., Danø, K., Kjøller, L. and Behrendt, N.:
A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor.
J.Biol.Chem. 2008, 283: 15217-15223.

Almholt, K., Juncker-Jensen, A., Green, K., Solberg, H., Lund, L.R, and Rømer. J.:
The plasminogen activation system in tissue remodelling and cancer invasion.
In “The Cancer Degradome – Proteases and Cancer Biology”, Edwards, D., Høyer-Hansen, G., Blasi, F., and Sloane, B.F., eds. Springer Verlag, 2007, 195-213.

Madsen, D.H., Engelholm, L.H., Ingvarsen, S., Hillig, T., Wagenaar-Miller, R.A., Kjøller, L., Gårdsvoll, H., Høyer-Hansen, G., Holmbeck, K., Bugge, T.H., Behrendt, N.:
Extracellular collagenases and the endocytic receptor, uPARAP/Endo180, cooperate in fibroblast-mediated collagen degradation.
J. Biol. Chem. 2007, 282:27037-27045.

Wagenaar-Miller, R.A., Engelholm, L.H., Kuhnen, M., Kahan, S., Yamada, S., Nielsen, B.S., Behrendt, N., Bugge, T.H. and Holmbeck, K.:
Complementary roles of intracellular and pericellular collagen degradation pathways in vivo.
Moll.Cell. Biol. 2007, 27: 6309-22

Almholt, K., Green, K., Juncker-Jensen, A., Nielsen, B.S., Lund, L.R., and Rømer, J.:
Extracellular proteolysis in transgenic mouse models of breast cancer. Mammary Gland Biology and Neoplasia, 2007, 12, 83-97.

Sulek, J., Shireman, J., Molinolo, A., Madsen, D.H., Engelholm, L.H., Behrendt, N., Wagenaar-Miller, R. and Bugge, T.H.:
Expression of the collagen internalization receptor uPARAP/Endo180 in stroma of oral squamous cell carcinoma.
J. Histochem.Cytochem. 2007, 55: 347-353.

Curino, A.C., Engelholm, L.H., Yamada, S.S., Holmbeck, K., Lund, L.R., Molinolo, A.A., Behrendt, N., Nielsen, B.S. & Bugge, T.H.:
Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy.
J. Cell. Biol. 2005, 169:977-985.

Larsen, M.B., Stephens, R.W., Brünner, N., Nielsen, H.J., Engelholm, L.H., Christensen, I.J., Stetler-Stevenson, W.G. & Høyer-Hansen, G.:
Quantitation of tissue inhibitor of metalloproteinases 2 in plasma from healthy donors and cancer patients.
Scand. J. Immunol. 2005, 61:449-460.

Kjøller, L., Engelholm, L.H., Høyer-Hansen, M., Danø, K., Bugge, T.H. & Behrendt, N.:
uPARAP/endo 180 directs lysosomal delivery and degradation of collagen.
Exp. Cell Res. 2004, 293:106-116.

Engelholm, L.H., List, K., Netzel Arnett, S., Cukierman, E., Mitola, D.J., Aaronson, H., Kjøller, L., Larsen, J.K., Yamada, K.M., Strickland, D.K., Holmback, K., Danø, K., Birkedal-Hansen, H., Behrendt, N. & Bugge, T.H.:
uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion.
J. Cell Biol. 2003, 160:1009-1015.

List, K., Haudenschild, C.C., Szabo, R., Chen, W.J., Wahl, S.M., Swaim, W., Engelholm, L.H., Behrendt, N. & Bugge, T.H.:
Matriptase / MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis.
Oncogene. 2002, 21:3765-3779.

Nielsen, B.S., Rank, F., Engelholm, L.H., Holm, A., Danø, K. & Behrendt, N.:
Urokinase receptor-associated protein (uPARAP) is expressed in connection with malignant as well as benign lesions of the human breast and occurs in specific populations of stromal cells.
Int. J. Cancer. 2002, 98:656-664.

Engelholm, L.H., Nielsen, B.S., Netzel-Arnett, S., Solberg, H., Chen, X.-D., Lopez Garcia, J.M., Lopez-Otin, C., Young, M.F., Birkedal-Hansen, H., Danø, K.., Lund, L.R., Behrendt, N. & Bugge, T.:
The urokinase plasminogen activator receptor-associated protein/Endo 180 is coexpressed with its interaction partners urokinase plasminogen activator receptor and matrix metalloprotease-13 during osteogenesis.
Lab. Invest. 2001, 81:1403-1414.

Ohlsson, H., Brünner, N., Engelholm, L.H., Lundholt, B.K., Weidle, U., Briand, P. & Lykkesfeldt, A.E.:
Identification of two estrogen regulated genes associated with growth regulation of human breast cancer.
Mol. Cell. Endocrinol. 2001, 182:1-11.

Engelholm, L.H., Nielsen, B.S., Danø, K., Behrendt, N.:
The urokinase receptor associated protein (uPARAP/Endo180): A novel internalization receptor connected to the plasminogen activation system.
Trends Cardiovasc. Med. 2001, 11:7-13.

Engelholm, L.H. & Behrendt, N.:
Differential binding of urokinase and peptide antagonists to the urokinase receptor: Evidence from characterization of the receptor in four primate species.
Biol. Chem. 2001, 382:435-442.