Behrendt Group

Key publications

Hillig, T., Engelholm, L.H., Ingvarsen, S., Madsen, D.H., Gårdsvoll, H., Larsen, J.K., Ploug, M., Danø, K., Kjøller, L. and Behrendt, N.:
A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor.
J. Biol. Chem., 2008, 283: 15217-15223.

Ingvarsen, S., Madsen, D.H., Hillig, T., Lund, L.R., Bugge, T.H., Holmbeck, K., Behrendt, N. and Engelholm, L.H.:
Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72 kDa gelatinase, MMP-2, on fibroblasts and fibrosarcoma cells.
Biol. Chem., 2008, 389: 943-953.

Madsen, D.H., Engelholm, L.H., Ingvarsen, S., Hillig, T., Wagenaar-Miller, R.A., Kjøller, L., Gårdsvoll, H., Høyer-Hansen, G., Holmbeck, K., Bugge, T.H. and Behrendt, N.:
Extracellular collagenases and the endocytic receptor, uPARAP/Endo180, cooperate in fibroblast mediated collagen degradation.
J. Biol. Chem., 2007, 282: 27037-27045.

Curino, A.C., Engelholm, L.H., Yamada, S.S., Holmbeck, K., Lund, L.R., Molinolo, A.A., Behrendt, N., Nielsen, B.S. and Bugge, T.H.:
Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy.
J. Cell Biol., 2005, 169: 977-985.

Behrendt, N.:
The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180): Membrane proteins engaged in matrix turnover during tissue remodeling.
Biol. Chem., 2004, 385: 103-136.

Kjøller, L., Engelholm, L.H., Høyer-Hansen, M., Danø, K., Bugge, T.H. and Behrendt, N.:
uPARAP/endo180 directs lysosomal delivery and degradation of collagen IV.
Exp. Cell Res., 2004, 293: 106-116.

Engelholm, L.H., List, K., Netzel-Arnett. S., Cukierman, E., Mitola, D.J., Aaronson, H., Kjøller, L., Larsen, J.K., Yamada, K.M., Strickland, D.K., Holmbeck, K., Danø, K., Birkedal-Hansen, H., Behrendt, N. and Bugge, T.H.:
uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion.
J. Cell Biol., 2003, 160: 1009-1015.

Schnack Nielsen, B., Rank, F., Engelholm, L. H., Holm, A., Danø, K. and Behrendt, N.:
The urokinase receptor-associated protein (uPARAP) is expressed in connection with malignant as well as benign lesions of the human breast and occurs in specific populations of stromal cells.
Int. J. Cancer, 2002, 98: 656-664.

Behrendt, N., Jensen, O. N., Engelholm, L. H., Mørtz, E., Mann, M. and Danø, K.:
A urokinase receptor-associated protein with specific collagen binding properties.
J. Biol. Chem., 2000, 275: 1993-2002.