The Cancer Degradome

The book “The Cancer Degradome” was published the 22. September 2008.
Gunilla Høyer-Hansen is one of the editors and and all research groups at the Finsen Laboratory have contributed with a chapter to the book. The relevant chapters are listed below.

Chapter 11
“The plasminogen activation system in tissue remodelling and cancer invasion”
Kasper Almholt, Anna Juncker-Jensen, Kirsty Anne Green, Helene Solberg, Leif Roge Lund & John Rømer

Chapter 13
“The endocytic collagen receptor uPARAP/Endo 180 in cancer invasion and tissue remodeling”
Thore Hillig, Lars H. Engelholm & Niels Behrendt

Chapter 28
“The plasminogen activation system as a source of prognostic markers in cancer”
Ib J.Christensen, Helle Pappot & Gunilla Høyer-Hansen

Chapter 34
“Structure and inhibition of the urokinase-type plasminiogen activator receptor (uPAR)”
Benedikte Jacobsen, Magnus Kjaergaard, Henrik Gårdsvoll & Michael Ploug

About the book
Proteases that act in the extracellular environment have been historically associated with tumorigenesis and metastasis by virtue of their ability to carry out "path-clearing" for cancer cells. In the past few years it has become clear that they also shape the pericellular signaling environment, with profound consequences for cell fate and phenotype in both normal development and disease states. The repertoire of proteases that cells and tissues coordinately regulate in order to modulate their local environment is the DEGRADOME – which in humans is represented by at least 569 proteases in five catalytic classes. "The Cancer Degradome: Proteases in Cancer Biology" , edited by Dylan Edwards, Francesco Blasi, Gunilla-Høyer-Hansen and Bonnie Sloane, covers recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; how protease activity can be imaged both in vitro and in vivo; how gene knockout mice have improved our knowledge of the roles of proteases in cancer; the links that have emerged between proteolysis and cell signaling; how the Degradome can be a useful source of diagnostic and prognostic markers; and finally new approaches to target proteolysis for therapy.