Niels Behrendt - Recent Publications

Szabova L, Yamada SS, Wimer H, Chrysovergis K, Ingvarsen S, Behrendt N, Engelholm LH, Holmbeck K.:
MT1-MMP and type II collagen specify skeletal stem cells and their bone and cartilage progeny.
J Bone Miner Res. 2009;24:1905-16.

Engelholm, L.H., Ingvarsen, S., Jürgensen, H.J., Hillig, T., Madsen, D.H., Nielsen, B.S. and Behrendt, N.:
"The collagen receptor uPARAP/Endo180."
Frontiers in Bioscience, 2009, 14: 2103-14.

Lund, I.K., Jögi, A., Rønø, B., Rasch, M.G., Lund, L.R., Almholt, K., Gårdsvoll, H., Behrendt, N., Rømer, J. and Høyer-Hansen, G.:
"Antibody-mediated targeting of the uPA proteolytic function. Neutralizes fibrinolysis in vivo."
J.Biol. Chem. 2008, 283: 32506-15.

Hillig, T., Engelholm, L.H., Ingvarsen, S., Madsen, D.H., Gårdsvoll, H., Larsen, J.K., Ploug, M., Danø, K., Kjøller, L. and Behrendt, N.:
A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor.
J. Biol. Chem. 2008, 283: 15217-15223.

Ingvarsen, S., Madsen, D.H., Hillig, T., Lund, L.R., Bugge, T.H., Holmbeck, K., Behrendt, N. and Engelholm, L.H.:
Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72 kDa gelatinase, MMP-2, on fibroblasts and fibrosarcoma cells.
Biol. Chem., 2008, 389: 943-953.

Madsen, D.H., Engelholm, L.H., Ingvarsen, S., Hillig, T., Wagenaar-Miller, R.A., Kjøller, L., Gårdsvoll, H., Høyer-Hansen, G., Holmbeck, K., Bugge, T.H. and Behrendt, N.:
Extracellular collagenases and the endocytic receptor, uPARAP/Endo180, cooperate in fibroblast mediated collagen degradation.
J. Biol. Chem. 2007, 282: 27037-27045.

Wagenaar-Miller, R.A., Engelholm, L.H., Gavard, J., Yamada, S.S., Gutkind, J.S., Behrendt, N., Bugge, T.H. and Holmbeck, K.:
Complementary roles of intracellular and pericellular collagen degradation pathways in vivo.
Mol. Cell. Biol. 2007, 27: 6309-6322.

Sulek, J., Wagenaar-Miller, R.A., Shireman, J., Molinolo, A., Madsen, D.H., Engelholm, L.H., Behrendt, N. and Bugge, T.H.:
Increased Expression of the Collagen Internalization Receptor uPARAP/Endo180 in the Stroma of Head and Neck Cancer.
J. Histochem. Cytochem. 2007, 55: 347-353.

Curino, A.C., Engelholm, L.H., Yamada, S.S., Holmbeck, K., Lund, L.R., Molinolo, A.A., Behrendt, N., Nielsen, B.S. and Bugge, T.H.:
Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy.
J. Cell Biol. 2005, 169: 977-985.

Danø, K., Behrendt, N., Høyer-Hansen, G., Johnsen, M., Lund, L.R., Ploug, M. and Rømer, J.:
Plasminogen activation and cancer.
Thromb. Haemost. 2005, 93: 676-681.

Udby, L., Sørensen, O.E., Pass, J., Johnsen, A.H., Behrendt, N., Borregaard, N. and Kjeldsen, L.:
Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma.
Biochemistry. 2004, 43: 12877-12886

Behrendt, N.:
The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180): Membrane proteins engaged in matrix turnover during tissue remodeling.
Biol. Chem. 2004, 385: 103-136.

Kjøller, L., Engelholm, L.H., Høyer-Hansen, M., Danø, K., Bugge, T.H. and Behrendt, N.:
uPARAP/endo180 directs lysosomal delivery and degradation of collagen IV.Exp.
Cell Res. 2004, 293: 106-116.

Engelholm, L.H., List, K., Netzel-Arnett. S., Cukierman, E., Mitola, D.J., Aaronson, H., Kjøller, L., Larsen, J.K., Yamada, K.M., Strickland, D.K., Holmbeck, K., Danø, K., Birkedal-Hansen, H., Behrendt, N. and Bugge, T.H.:
uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion.
J. Cell Biol. 2003, 160: 1009-1015.

Behrendt, N., List, K., Andreasen, P.A. and Danø, K.:
The pro-urokinase plasminogen-activation system in the presence of serpin-type inhibitors and the urokinase receptor: rescue of activity through reciprocal pro-enzyme activation.
Biochem J. 2003, 371: 277-287.

List, K., Haudenschild, C.C., Szabo, R., Chen, W., Wahl, S.M., Swaim, W., Engelholm, L.H., Behrendt, N. and Bugge, T.H.:
Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis.
Oncogene. 2002, 21: 3765-3779.

Schnack Nielsen, B., Rank, F., Engelholm, L. H., Holm, A., Danø, K. and Behrendt, N.:
The urokinase receptor-associated protein (uPARAP) is expressed in connection with malignant as well as benign lesions of the human breast and occurs in specific populations of stromal cells.
Int. J. Cancer. 2002, 98: 656-664.

Engelholm, L. H., Nielsen, B. S., Netzel-Arnett, S., Solberg, H., Chen, X.-D., Lopez-Garcia, J. M., Lopez-Otin, C., Young, M. F., Birkedal-Hansen, H., Danø, K., Lund, L. R., Behrendt, N. and Bugge, T. H.:
The urokinase plasminogen activator receptor-associated protein/Endo180 is coexpressed with its interaction partners uPAR and matrix metalloprotease-13 during osteogenesis.
Lab. Invest. 2001, 81: 1403-1414.

Høyer-Hansen, G., Pessara, U., Holm, A., Pass, J., Weidle, U., Danø, K. and Behrendt, N.:
Urokinase-catalysed cleavage of the urokinase receptor requires an intact glycolipid anchor.
Biochem. J 2001, 358: 673-679.

Engelholm, L.H., Nielsen, B. S., Danø, K. and Behrendt, N.:
The urokinase receptor associated protein (uPARAP/Endo180): A novel internalization receptor connected to the plasminogen activation system.
Trends Cardiovasc. Med 2001, 11: 7-13.

Engelholm, L. H. and Behrendt, N.:
Differential binding of urokinase and peptide antagonists to the urokinase receptor: Evidence from characterization of the receptor in four primate species.
Biol. Chem. 2001, 382: 435-442.