Niels Behrendt

Ph.d., DSc.

Acting Head of Finsen Laboratory & Group Leader

See full curriculum vitae here

Key Research Interests
The projects of the group are focused on cellular invasion and matrix degradation through extracellular and endocytic mechanisms, with particular emphasis to collagenolysis. The work includes multidisciplinary studies on the protein structure, cellular function and physiological role of collagen receptors and collagenolytic proteases. The proteins particularly in focus are uPARAP/Endo180 and other endocytic receptors for extracellular matrix proteins, as well as membrane-type matrix metalloproteases (MT-MMPs).

Current Projects
Elucidation of the interplay between extracellular proteolysis and endocytic matrix breakdown in tissue remodeling and cancer invasion. The collagen receptor, uPARAP/Endo180 and related receptors.MT-MMPs and their role in pericellular and extracellular collagenolysis. Strategies for interfering with collagen turnover in vivo, with particular emphasis to blocking monoclonal antibodies.