Michael Ploug - Key publications

Li,Z-B., Niu, G., Wang, H., He, L., Yang, L., Ploug, M., and Chen, X.: "Imaging of urokinase-type plasminogen activator receptor expression using a 64Cu-labeled linear peptide antagonist by microPET"
Clin. Cancer Res. 2008, 14: 4758-4766.

Hansen, L.V., Lærum, O.D., Illemann, M., Nielsen, B.S., and Ploug, M.:
"Altered expression of the urokinase receptor homologue, C4.4A, in invasive areas of human esophageal squamous cell carcinoma"
Int. J. Cancer. 2008, 122: 734-741.

Gårdsvoll, H. and Ploug, M.:
"Mapping of the vitronectin binding site on the urokinase receptor. Involvement of a coherent receptor interface comprising residues from both domain I and the flanking interdomain linker region"
J. Biol. Chem. 2007, 282: 13561-135726.

Gårdsvoll, H., Gilquin, B., LeDu, M.H., Ménez, A., Jørgensen, T.D.J. and Ploug, M.:
"Charaterization of the functional epitope on the urokinase receptor. Complete alanine scanning mutagenesis supplemented by chemical crosslinking"
J. Biol. Chem. 2006, 281: 19260-192725.

Jørgensen, T.J., Bache, N., Gårdsvoll, H., Roepstorff, P. and Ploug, M.:
"Collisional activation by MALDI tandem time-of-flight mass spectrometry induces intramolecular migration of amide hydrogens in protonated peptides"
Mol. Cell. Proteomics. 2005, 4: 1910-1919.

Llinas, P., Le Du, M., Gårdsvoll, H., Danø, K., Ploug, M., Gilquin, B., Stura, E.A., and Ménez, A.:
"Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide"
EMBO J. 2005, 24: 1655-16633.

Ploug, M., Østergaard, S., Gårdsvoll, H., Kovalski, K., Holst-Hansen, C., Holm, A., Ossowski, L., and Danø, K.:
"Peptide derived antagonists of the urokinase receptor. Affinity maturation by combinatorial chemistry, identification of functional epitopes, and inhibitory effects on cancer cell intravasation"
Biochemistry. 2001, 40: 12157-121682.