Marie Sigurd Hasemann

Senior scientist


Key Research Interests
Hematopoiesis, Leukemia, Stem cells, transcription factors, lineage priming, epigenetic marks

Current Project
Transcription factors play a key role in lineage commitment and differentiation of hematopoietic stem cells (HSCs) into distinct mature cells. In hematopoiesis they regulate lineage-specific gene expression in a stage-specific manner through various physical and functional interactions with regulatory proteins that are simultanously recruited and activated to ensure timely gene expression. In line with this important role, deregulation of transcription factors can drive leukemogenic onset. I am trying to elucidate the role of key transcription factors in HSCs using phenotypic, functional and mechanistic assays.


Career
2011-present: Senior scientist, Finsen Laboratory, Rigshospitalet
2008-2011: Post Doc, Biotech Research and Innovation Centre, University of Copenhagen
2007-2008: Post Doc, Section for Gene Therapy Research, Rigshospitalet
2007: Ph. D., Molecular Biology, University of Copenhagen
2003-2007: Ph. D. StudentSection for Gene Therapy Research, Rigshospitalet
2002: Scientific assistant, Danish Cancer Society, Dept. of Cell cycle and Cancer
2002: M. Sc., Molecular Biology, University of Copenhagen