Contact information

Telephone: +45 3545 4660

Email:
jsjakobsen(at)finsenlab.dk

Room no.: 3.3.41

Publications

Key publications

Recent publications

Janus S. Jakobsen

Ph.d.

Postdoctoral fellow

Key Research Interests
Eukaryotic transcriptional regulation, embryonic development and specific transcription, erroneous regulation in stem cells leading to transformation, transcriptional codes by panels of transcription factors, integration of external and internal informational cues regulating transcription.

Current project
Epithelial cancers, such as skin and mammae gland cancers, account for >90% of human neoplasias, and are among the most common causes of death in the Western world. Many epithelial cancers display significantly increased levels of Cyclin D1, which has been found to be essential for Ras-pathway induced tumorigenesis. Tumors with increased expression of genes dependent on Cyclin D1 has futhermore consistently been found to overexpress the transcription factor C/EBP-beta. This transcription factor is, like Cyclin D1, required for Ras-induced cancerogenesis, and was demonstrated to form a physical complex with Cyclin D1. We are investigating how the Ras-pathway affects the complex formation between C/EBPbeta and Cyclin D1. Our observations are consistent with Ras promoting C/EBP-beta-Cyclin D1 association to mediate epithelial cancer formation.

My project aims to investigate if a common program or individual effector genes of epithelial cancerogenesis, driven by the C/EBP-beta-Cyclin D1 complex, can be indentified. This will be done by genomic methods; expression profiling and ChIP-on-chip.

Career
1994: Enrolled at University of Copenhagen, Biology1997 Bachelor, Bach. Scient., Biology

2001: Master of Science (Human Biology), Cand. Scient.
Masters research project at Laboratory of Molecular Pharmacology lead by Thue Schwartz. University of Copenhagen.

2002: Initiated PhD level studies at EMBL, European Molecular Biology Laboratory, Heidelberg, Germany, at Department of Developmental Biology.

2007: Achieved PhD in Molecular Biology at EMBL and University of Copenhagen (partnership agreement).Research project done at Eileen Furlong’s laboratory at EMBL.